![]() There was no radiographic evidence of acute pulmonary disease on the chest X-ray. ![]() An electrocardiogram showed sinus tachycardia. Initial laboratory investigations revealed mild leukocytosis, normochromic normocytic anemia, elevated reticulocyte count, total bilirubin, lactate dehydrogenase, and possibly acute kidney injury (Table 1). Physical examination did not reveal significant findings other than altered mental status. The patient was not articulating or able to communicate history. On triage, the patient had a body temperature of 98.2 degrees Fahrenheit, blood pressure of 143/96 mmHg, heart rate of 113 beats per minute, respiratory rate of 18 breaths per minute, oxygen saturation of 96% in room air, and blood sugar of 213 mg/dL. The patient also had a history of smoking a pack of cigarettes per day for about 20 years. She stated that at baseline, the patient was able to communicate well, ambulate with a cane, and required assistance with activities of daily living. The following day, she found that the patient continued to respond with “Ok” to her questions. According to her home health aide, when she visited the patient a day before, the patient responded with “Ok” to pleasantries. Case PresentationĪ 57-year-old woman with a history of hypertension, diabetes mellitus, obesity, asthma, and HbSC disease presented to the emergency department after she was found having altered mental status. We describe the case of a 57-year-old woman with HbSC disease presenting with altered mental status, which turned out to be due to acute ischemic stroke. However, recent retrospective studies in 20 noted a higher prevalence of neurovascular complications in these patients, with an overall prevalence of 17.7% (2.9% overt stroke, 8.8 to 13.5% silent stroke, and 5.9% vasculopathy). Moreover, the Cooperative Study of Sickle Cell Disease (CSSCD) in 2002 revealed that the prevalence of overt and silent stroke in patients with HbSC disease was 0% and 5.8%, respectively. Because many people with HbSC disease emigrate from countries without newborn screening, they may only be diagnosed when a disease-related complication arises.Īlthough HbSC disease is considered a milder variant of SCD, it is associated with multiple systemic complications such as painful crises, ocular, splenic, neurological, cardiovascular, and pulmonary complications, and priapism. On the other hand, it accounts for more than 50% of SCD in some areas of West Africa where HbC originated. It accounts for nearly 30% of sickle cell disease (SCD) in the United States of America and the United Kingdom. ![]() Hemoglobin SC (HbSC) disease is due to co-inheritance of the hemoglobin S (HbS) and hemoglobin C (HbC) beta-globin gene mutations.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |